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The interplay between the microbiota, the epigenome, and nutrition among obese adults during behavioral weight reduction

Study evaluated associations between gut microbiome (MB), deoxyribonucleic acid (DNA) methylation (DNAme), and nutrition.

21 Aug 2023

Early lung cancer detection with a machine learning model based on imaging, clinical, and DNA methylation biomarkers

Researchers discuss the development and validation of a combined model for the early diagnosis of lung cancer.

15 Aug 2023

Epigenetic manipulation may improve breast cancer treatment responses

Researchers explore the possibility of increasing TROP2 ADC activity by enhancing the expression of TROP2 on cancer cells.

15 Aug 2023

Epigenetic drug-sensitive biomarkers for cancer

Researchers perform an epigenome-wide multi-omic high-throughput screen to identify actionable epigenetic drug-sensitive biomarkers.

15 Aug 2023

Study reveals the health and dietary benefits of consuming cardamom

A new study by Texas A&M AgriLife revealed a range of health and dietary benefits of consuming cardamom, including increased appetite, fat loss and inflammation reduction, making the spice a "superfood."

13 Aug 2023

Study reveals APOE-ε4 allele increases the risk for Alzheimer's and cardiovascular disease

Previous research has revealed that the Apolipoprotein-ε4 (APOE-ε4) allele increases the risk for a variety of diseases in aging populations, specifically Alzheimer's and cardiovascular disease. And yet, despite the negative effects of this genetic variant, it remains prevalent in approximately 20% of the human population.

11 Aug 2023

Recent advances in the understanding of the role and mechanism of CCAR2 in cancer

Researchers described the dual role of cell cycle and apoptosis regulator 2 (CCAR2) in cancer progression as a tumor suppressor and promoter.

4 Aug 2023

Transcription factors may drive development of different colorectal cancer subtypes

New research in colorectal cancers directed by investigators at the Johns Hopkins Kimmel Cancer Center suggests that expression of transcription factors — proteins that help turn specific genes on or off by binding to nearby DNA — may play a central role in the degree of DNA methylation across the genome, contributing to the development of different subtypes of these cancers.

27 Jul 2023

Core promoter variation may drive development of triple-negative breast cancer

TNBC is a particularly aggressive subtype of breast cancer, characterized by the absence of three key receptors: estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2).

26 Jul 2023

Can epigenetic changes explain the strong link between age and cancer?

Researchers reported the link between aging, cancer, and epigenomic changes.

26 Jul 2023

The role of airway epithelium: insights into asthma and COPD pathogenesis

Study discussed how injury and abnormal repair of the airway epithelium drive chronic obstructive pulmonary disease (COPD) and asthma.

17 Jul 2023

Breast cancer and MEN1: exploring the connection

Researchers evaluated the role of Multiple Endocrine Neoplasia 1 (MEN1) messenger ribonucleic acid (mRNA) in breast cancer

17 Jul 2023

Researchers demonstrate targeted epigenome editing in the promoter region of several genes using sgRNA/dCas9 complexes

Researchers develop and characterize a highly specific EpiEditing system using catalytically inactivated catalytically inactivated Cas9.

17 Jul 2023

Smoking and HPV found to increase risk of head and neck cancer

Tobacco smoking and human papillomavirus (HPV) are both well-known risk factors for head and neck cancer, but there is ample evidence to show they can interact to increase still further the risk of contracting the disease, according to a study by scientists at the University of São Paulo (USP) in Brazil and the University of Chile.

3 Jul 2023

Base editing shows promise for treating sickle cell disease and beta thalassemia

Gene therapy that alters hemoglobin genes may be an answer to curing sickle cell disease (SCD) and beta thalassemia.

3 Jul 2023

Scientists visualize dynamic motion of gene regions on chromosomes

Despite being densely packed to fit into the nucleus, chromosomes storing our genetic information are always in motion.

29 Jun 2023

"Homing gene drive system" could help suppress agricultural pests

Researchers have developed a "homing gene drive system" based on CRISPR/Cas9 that could be used to suppress populations of Drosophila suzukii vinegar flies – so-called "spotted-wing Drosophila" that devastate soft-skinned fruit in North America, Europe and parts of South America – according to new research from North Carolina State University.

12 Jun 2023

Unlocking the potential of melatonin: A promising epigenetic weapon against cancer

Melatonin, a hormone derived from the pineal gland, has diverse effects on cellular processes. This review explores its potential role as an epigenetic regulator, particularly in modulating DNA methylation, and suggests its use in combination therapy as a novel anticancer strategy.

30 May 2023

Researchers use machine learning to identify "synthetic extreme" DNA sequences

Artificial intelligence has exploded across our news feeds, with ChatGPT and related AI technologies becoming the focus of broad public scrutiny.

19 May 2023

New technique generates highest-resolution maps of the 3D genome

Much of the human genome is made of regulatory regions that control which genes are expressed at a given time within a cell.

8 May 2023

Promoter News and Research

The interplay between the microbiota, the epigenome, and nutrition among obese adults during behavioral weight reduction

Early lung cancer detection with a machine learning model based on imaging, clinical, and DNA methylation biomarkers

Epigenetic manipulation may improve breast cancer treatment responses

Epigenetic drug-sensitive biomarkers for cancer

Study reveals the health and dietary benefits of consuming cardamom

Study reveals APOE-ε4 allele increases the risk for Alzheimer's and cardiovascular disease

Recent advances in the understanding of the role and mechanism of CCAR2 in cancer

Transcription factors may drive development of different colorectal cancer subtypes

Core promoter variation may drive development of triple-negative breast cancer

Can epigenetic changes explain the strong link between age and cancer?

The role of airway epithelium: insights into asthma and COPD pathogenesis

Breast cancer and MEN1: exploring the connection

Researchers demonstrate targeted epigenome editing in the promoter region of several genes using sgRNA/dCas9 complexes

Smoking and HPV found to increase risk of head and neck cancer

Base editing shows promise for treating sickle cell disease and beta thalassemia

Scientists visualize dynamic motion of gene regions on chromosomes

"Homing gene drive system" could help suppress agricultural pests

Unlocking the potential of melatonin: A promising epigenetic weapon against cancer

Researchers use machine learning to identify "synthetic extreme" DNA sequences

New technique generates highest-resolution maps of the 3D genome

Unleashing the Power of Microfluidic Picodroplets

Ensuring colony counts remain precise and verifiable using a completely automated colony counting system

Pharmatech: The Art of AI-Driven Drug Design with Exscientia

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